MolNFT v1 · #153631 · protein
The NAD+-free form of human nsdhl
6JKG · Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating: “The NAD+-free form of human nsdhl”. X-ray diffraction, 5 pockets (best druggability 0.61). MolNFT v1 #153631 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6JKG
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
- EC
- 1.1.1.170
- UniProt
- Q15738
- Pockets
- 5 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) | protein | 216 | 38% helix, 20% strand | Q15738 |
| B | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) | protein | 211 | 35% helix, 22% strand | Q15738 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 305 | 0.61 | 0.78 | 48 | empty |
| 2 | 177 | 0.57 | 0.81 | 36 | empty |
| 3 | 92 | 0.51 | 0.83 | 20 | empty |
| 4 | 59 | 0.50 | 0.86 | 14 | empty |
| 5 | 187 | 0.50 | 0.77 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 2296 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15738
- Elsewhere: RCSB PDB 6JKG · PDBe 6JKG · UniProt Q15738
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