MolNFT v1 · #15360 · protein
Ternary complex of MLC1P bound to IQ2 and IQ3 of MYO2P, a class V myosin
1N2D · Myosin light chain: “Ternary complex of MLC1P bound to IQ2 and IQ3 of MYO2P, a class V myosin”. X-ray diffraction, 3 pockets (best druggability 0.53). MolNFT v1 #15360 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1N2D
- Type
- protein
- Length
- 340 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin light chain; IQ2 and IQ3 motifs from MYO2P, a class V myosin
- UniProt
- P53141, P19524
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 3 distinct chains · 65% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin light chain | protein | 147 | 61% helix, 8% strand | P53141 |
| B | Myosin light chain | protein | 145 | 59% helix, 7% strand | P53141 |
| C | IQ2 and IQ3 motifs from MYO2P, a class V myosin | protein | 48 | 94% helix, 0% strand | P19524 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 293 | 0.53 | 0.75 | 31 | empty |
| 2 | 147 | 0.44 | 0.75 | 24 | empty |
| 3 | 53 | 0.27 | 0.74 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1433 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1203 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 49 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1N2D · Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin · the same entry in another collection · chain A against A, TM-score 1.00
- P19524 · AlphaFold monomer V2.0 prediction for myosin-2 (P19524) · a predicted model of the same protein · chain C against A, TM-score 0.92
- P53141 · AlphaFold monomer V2.0 prediction for myosin light chain 1 (P53141) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53141
- Every structure of UniProt P19524
- Elsewhere: RCSB PDB 1N2D · PDBe 1N2D · UniProt P53141 · UniProt P19524
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