MolNFT v1 · #153477 · protein

MITOFUSIN2 (MFN2)_T111D

6JFM · Mitofusin-2,MITOFUSIN-2: “MITOFUSIN2 (MFN2)_T111D”. X-ray diffraction, 1 ligand (CA), 8 pockets (best druggability 0.77). MolNFT v1 #153477 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JFM
Type: protein
Length: 841 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitofusin-2,MITOFUSIN-2
EC: 3.6.5.-
UniProt: O95140, G7MGV9
Ligands: CA
Pockets: 8 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 62% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitofusin-2,MITOFUSIN-2 (EC 3.6.5.-)	protein	419	62% helix, 12% strand	O95140, G7MGV9
B	Mitofusin-2,MITOFUSIN-2 (EC 3.6.5.-)	protein	422	62% helix, 11% strand	O95140, G7MGV9

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains A, B
ACT · Acetate ion · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	959	0.77	0.80	105	ACT
2	433	0.64	0.78	37	empty
3	379	0.63	0.78	38	empty
4	287	0.55	0.76	33	empty
5	84	0.52	0.85	26	empty

Interfaces

1 interface between chains.

A–B · 1501 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

6JFM · Mitofusin2 (MFN2)_T111D · the same entry in another collection · chain A against A, TM-score 1.00
O95140 · AlphaFold monomer V2.0 prediction for mitofusin-2 (O95140) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95140
Every structure of UniProt G7MGV9
Elsewhere: RCSB PDB 6JFM · PDBe 6JFM · UniProt O95140 · UniProt G7MGV9

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