MolNFT v1 · #153476 · protein

Nucleotide-free MITOFUSIN2 (MFN2)

6JFL · Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane…: “Nucleotide-free MITOFUSIN2 (MFN2)”. X-ray diffraction, 1 ligand (CA), 19 pockets (best druggability 0.78). MolNFT v1 #153476 on GenesisL1: 3D structure, binding sites and…

PDB: 6JFL
Type: protein
Length: 1,653 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane GTPase MFN2
EC: 3.6.5.-
UniProt: O95140, B7Z3H8
Ligands: CA
Pockets: 19 · best druggability 0.78

Structure

x-ray diffraction · 4 distinct chains · 61% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane GTPase MFN2 (EC 3.6.5.-)	protein	413	61% helix, 11% strand	O95140, B7Z3H8
B	Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane GTPase MFN2 (EC 3.6.5.-)	protein	413	61% helix, 12% strand	O95140, B7Z3H8
C	Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane GTPase MFN2 (EC 3.6.5.-)	protein	412	62% helix, 11% strand	O95140, B7Z3H8
D	Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane GTPase MFN2 (EC 3.6.5.-)	protein	415	61% helix, 12% strand	O95140, B7Z3H8

Ligands and binding sites

CA · Calcium ion · metal · chains C
GOL · Glycerol · additive · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1128	0.78	0.80	97	empty
2	568	0.75	0.82	63	empty
3	881	0.74	0.78	58	empty
4	383	0.67	0.81	36	GOL
5	511	0.66	0.78	40	empty

Interfaces

4 interfaces between chains.

B–D · 1587 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 1472 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 359 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 313 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6JFL · Nucleotide-free Mitofusin2 (MFN2) · the same entry in another collection · chain D against D, TM-score 1.00
O95140 · AlphaFold monomer V2.0 prediction for mitofusin-2 (O95140) · a predicted model of the same protein · chain C against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95140
Every structure of UniProt B7Z3H8
Elsewhere: RCSB PDB 6JFL · PDBe 6JFL · UniProt O95140 · UniProt B7Z3H8

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