MolNFT v1 · #153203 · protein

Crystal structure of mouse ryanodine receptor 2 SPRY1 domain (650-844) disease mutant I784F

6J6L: “Crystal structure of mouse ryanodine receptor 2 SPRY1 domain (650-844) disease mutant I784F”. X-ray diffraction, 9 pockets (best druggability 0.57). MolNFT v1 #153203 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6J6L
Type: protein
Length: 379 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ryanodine receptor 2
UniProt: E9Q401
Pockets: 9 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ryanodine receptor 2	protein	190	5% helix, 42% strand	E9Q401
B	Ryanodine receptor 2	protein	189	5% helix, 43% strand	E9Q401

Ligands and binding sites

IPA · Isopropyl alcohol · additive · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.57	0.91	18	empty
2	52	0.54	0.89	16	empty
3	105	0.42	0.77	27	IPA
4	90	0.34	0.74	22	empty
5	75	0.34	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 1371 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

6J6L · Crystal structure of mouse Ryanodine Receptor 2 SPRY1 Domain (650-844) disease mutant… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E9Q401
Elsewhere: RCSB PDB 6J6L · PDBe 6J6L · UniProt E9Q401

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