MolNFT v1 · #15309 · protein

Crystal structure of elongation factor 2

1N0V: “Crystal structure of elongation factor 2”. X-ray diffraction, 17 pockets (best druggability 0.81). MolNFT v1 #15309 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1N0V
Type: protein
Length: 1,650 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Elongation factor 2
UniProt: P32324
Pockets: 17 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, D	Elongation factor 2	protein	825	37% helix, 26% strand	P32324

Pockets

17 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	993	0.81	0.82	99	empty
2	630	0.78	0.83	56	empty
3	743	0.67	0.75	76	empty
4	474	0.62	0.76	53	empty
5	211	0.51	0.76	20	empty

Interfaces

1 interface between chains.

C–D · 184 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1N0V · Crystal structure of elongation factor 2 · the same entry in another collection · chain C against C, TM-score 1.00
P32324 · AlphaFold monomer V2.0 prediction for elongation factor 2 (P32324) · a predicted model of the same protein · chain D against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32324
Elsewhere: RCSB PDB 1N0V · PDBe 1N0V · UniProt P32324

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