MolNFT v1 · #153057 · protein

WWP1 close conformation

6J1X · NEDD4-like E3 ubiquitin-protein ligase WWP1: “WWP1 close conformation”. X-ray diffraction, 6 pockets (best druggability 0.76). MolNFT v1 #153057 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6J1X
Type: protein
Length: 473 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NEDD4-like E3 ubiquitin-protein ligase WWP1
EC: 2.3.2.26
UniProt: Q9H0M0
Pockets: 6 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26)	protein	473	43% helix, 17% strand	Q9H0M0

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	906	0.76	0.79	97	empty
2	161	0.68	0.87	24	empty
3	210	0.52	0.77	35	GOL
4	129	0.51	0.80	22	empty
5	102	0.34	0.73	25	empty

Compared structures

6J1X · WWP1 close conformation · the same entry in another collection · chain B against B, TM-score 1.00
Q9H0M0 · AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP1 (Q9H0M0) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H0M0
Elsewhere: RCSB PDB 6J1X · PDBe 6J1X · UniProt Q9H0M0

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