UniProt Q9H0M0
NEDD4-like E3 ubiquitin-protein ligase WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (UniProt Q9H0M0), EC 2.3.2.26, 6.3.2.-: 14 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 64 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9H0M0
- Protein
- NEDD4-like E3 ubiquitin-protein ligase WWP1
- EC
- 2.3.2.26, 6.3.2.-
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 64 · 8 records with a druggable one
Structures
15 records of Q9H0M0 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ND7 | Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase | x-ray diffraction | A | — | 3 (best 0.79) |
| 1ND7 | Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 hect domain E3 ligase | x-ray diffraction | A | — | — |
| 2OP7 | WW4 | solution nmr | A | — | — |
| 2OP7 | WW4 | solution nmr | A | — | — |
| 5HPS | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1 and UbV P1.1 | x-ray diffraction | A | — | 5 (best 0.77) |
| 5HPS | System-wide modulation of hect E3 ligases with selective ubiquitin variant probes: WWP1 and ubv P1.1 | x-ray diffraction | A | — | — |
| 5HPT | System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1, Ubv P2.3… | x-ray diffraction | A, D, G | — | 15 (best 0.84) |
| 5HPT | System-wide modulation of hect E3 ligases with selective ubiquitin variant probes: WWP1, ubv P2.3… | x-ray diffraction | A, D, G | — | — |
| 6J1X | WWP1 close conformation | x-ray diffraction | B | — | 6 (best 0.76) |
| 6J1X | WWP1 close conformation | x-ray diffraction | B | — | — |
| 6J1Y | Semi-open conformation E3 ligase | x-ray diffraction | A, B | — | 11 (best 0.79) |
| 6J1Y | Semi-open conformation E3 ligase | x-ray diffraction | A, B | — | — |
| 8EI4 | Crystal structure of the WWP1 HECT domain in complex with H302, a Helicon Polypeptide | x-ray diffraction | A | WHL | 3 (best 0.78) |
| 9EQK | WWP1 WW2-2,3-linker-WW3-WW4-HECT (WWP1-2L34H) with ordered WW2 domain | x-ray diffraction | A, B | — | 14 (best 0.82) |
| Q9H0M0 | AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP1 (Q9H0M0) | predicted | A | — | 7 (best 0.82) |
Ligands
- WHL · N,N'-(1,4-phenylene)diacetamide · in 1 record
Experiment against prediction
- 8EI4 chain A against the predicted model Q9H0M0: TM-score 0.98, RMSD 1.02 Å
- 6J1Y chain B against the predicted model Q9H0M0: TM-score 0.98, RMSD 1.33 Å
- 6J1Y chain B against the predicted model Q9H0M0: TM-score 0.98, RMSD 1.33 Å
- 5HPS chain A against the predicted model Q9H0M0: TM-score 0.97, RMSD 1.24 Å
- 5HPS chain A against the predicted model Q9H0M0: TM-score 0.97, RMSD 1.24 Å
- 6J1X chain B against the predicted model Q9H0M0: TM-score 0.97, RMSD 1.69 Å
- 6J1X chain B against the predicted model Q9H0M0: TM-score 0.97, RMSD 1.69 Å
- 6J1Y chain A against the predicted model Q9H0M0: TM-score 0.97, RMSD 1.44 Å
- 6J1Y chain A against the predicted model Q9H0M0: TM-score 0.97, RMSD 1.44 Å
- 5HPT chain G against the predicted model Q9H0M0: TM-score 0.96, RMSD 1.47 Å
Elsewhere
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