MolNFT v1 · #152974 · protein
Structural basis for activity of tric counter-ion channels in calcium release
6IZF · Trimeric intracellular cation channel type a: “Structural basis for activity of tric counter-ion channels in calcium release”. X-ray diffraction, 3 ligands (BQ9, CA, CL), 1 pocket (best druggability 0.65). MolNFT v1 #152974 on…
- PDB
- 6IZF
- Type
- protein
- Length
- 224 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trimeric intracellular cation channel type a
- UniProt
- Q5ZK43
- Ligands
- BQ9, CA, CL
- Pockets
- 1 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trimeric intracellular cation channel type a | protein | 224 | 79% helix, 0% strand | Q5ZK43 |
Ligands and binding sites
- BQ9 · (2R)-1-(dodecanoyloxy)-3-hydroxypropan-2-yl (5E,8E, 11E)-tetradeca-5,8,11-trienoate · ligand · chains A
- CA · Calcium ion · metal · chains A
- CL · Chloride ion · ion · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 357 | 0.65 | 0.80 | 34 | CL |
Compared structures
- 6IZF · Structural basis for activity of TRIC counter-ion channels in calcium release · the same entry in another collection · chain A against A, TM-score 1.00
- Q5ZK43 · AlphaFold monomer V2.0 prediction for trimeric intracellular cation channel type a… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZK43
- Elsewhere: RCSB PDB 6IZF · PDBe 6IZF · UniProt Q5ZK43
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