MolNFT v1 · #152953 · protein
Crystal structure of the acyltransferase domain from second module 14 of salinomycin polyketide synthase
6IYT · Type I modular polyketide synthase: “Crystal structure of the acyltransferase domain from second module 14 of salinomycin polyketide synthase”. X-ray diffraction, 3 pockets (best druggability 0.69). MolNFT v1 #152953 on GenesisL1…
- PDB
- 6IYT
- Type
- protein
- Length
- 856 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type I modular polyketide synthase
- UniProt
- H1ZZU1
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Type I modular polyketide synthase | protein | 432 | 44% helix, 16% strand | H1ZZU1 |
| B | Type I modular polyketide synthase | protein | 424 | 45% helix, 16% strand | H1ZZU1 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 663 | 0.69 | 0.77 | 79 | empty |
| 2 | 684 | 0.67 | 0.76 | 59 | empty |
| 3 | 291 | 0.66 | 0.82 | 44 | empty |
Interfaces
1 interface between chains.
- A–B · 146 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6IYT · Crystal Structure of the acyltransferase domain from second module 14 of salinomycin… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H1ZZU1
- Elsewhere: RCSB PDB 6IYT · PDBe 6IYT · UniProt H1ZZU1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.