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Crystal structure of the acyltransferase domain from second module 14 of salinomycin polyketide synthase

Analyse Crystal structure of the acyltransferase domain from second module 14 of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6IYT
Type: protein
Length: 856 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Type I modular polyketide synthase
UniProt: H1ZZU1
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Type I modular polyketide synthase	protein	432	44% helix, 16% strand	H1ZZU1
B	Type I modular polyketide synthase	protein	424	45% helix, 16% strand	H1ZZU1

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	663	0.69	0.77	79	empty
2	684	0.67	0.76	59	empty
3	291	0.66	0.82	44	empty

Interfaces

1 interface between chains.

A–B · 146 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6IYT · Crystal Structure of the acyltransferase domain from second module 14 of salinomycin… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H1ZZU1
Elsewhere: RCSB PDB 6IYT · PDBe 6IYT · UniProt H1ZZU1

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