MolNFT v1 · #152876 · protein

Crystal structure of importin-alpha and phosphoserine GM130

6IWA: “Crystal structure of importin-alpha and phosphoserine GM130”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #152876 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6IWA
Type: protein
Length: 455 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoserine GM130; Importin subunit alpha-1
UniProt: Q08379, P52293
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoserine GM130	protein	28	21% helix, 0% strand	Q08379
C	Importin subunit alpha-1	protein	427	73% helix, 0% strand	P52293

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	119	0.49	0.80	15	empty
2	84	0.47	0.81	13	empty

Interfaces

1 interface between chains.

A–C · 1597 Å² buried · 36 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

6IWA · Crystal structure of Importin-alpha and phosphoserine GM130 · the same entry in another collection · chain A against A, TM-score 1.00
Q08379 · AlphaFold monomer V2.0 prediction for golgin subfamily a member 2 (Q08379) · a predicted model of the same protein · chain A against A, TM-score 0.31

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08379
Every structure of UniProt P52293
Elsewhere: RCSB PDB 6IWA · PDBe 6IWA · UniProt Q08379 · UniProt P52293

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