MolNFT v1 · #152875 · protein
Crystal structure of importin-alpha and wild-type GM130
6IW8 · Peptide from golgin subfamily a member 2: “Crystal structure of importin-alpha and wild-type GM130”. X-ray diffraction, 2 pockets (best druggability 0.50). MolNFT v1 #152875 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6IW8
- Type
- protein
- Length
- 447 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptide from golgin subfamily a member 2; Importin subunit alpha-1
- UniProt
- Q08379, P52293
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptide from golgin subfamily a member 2 | protein | 28 | 29% helix, 0% strand | Q08379 |
| C | Importin subunit alpha-1 | protein | 419 | 74% helix, 0% strand | P52293 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.50 | 0.77 | 27 | empty |
| 2 | 60 | 0.28 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–C · 1607 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08379
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 6IW8 · PDBe 6IW8 · UniProt Q08379 · UniProt P52293
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