MolNFT v1 · #152566 · protein
Yap-binding domain of human TEAD1
6IM5 · Transcriptional enhancer factor tef-1: “Yap-binding domain of human TEAD1”. X-ray diffraction, 1 ligand (PO4), 6 pockets (best druggability 0.84). MolNFT v1 #152566 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6IM5
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-1
- UniProt
- P28347
- Ligands
- PO4
- Pockets
- 6 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transcriptional enhancer factor tef-1 | protein | 216 | 16% helix, 51% strand | P28347 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.84 | 0.96 | 37 | empty |
| 2 | 232 | 0.84 | 0.96 | 35 | empty |
| 3 | 531 | 0.68 | 0.78 | 58 | empty |
| 4 | 91 | 0.36 | 0.75 | 23 | empty |
| 5 | 58 | 0.29 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1035 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28347
- Elsewhere: RCSB PDB 6IM5 · PDBe 6IM5 · UniProt P28347
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