MolNFT v1 · #152386 · protein
Crystal structure of chimeric ksga with loop 12 from erm
6IFX · Ribosomal RNA small subunit methyltransferase a: “Crystal structure of chimeric ksga with loop 12 from erm”. X-ray diffraction, 8 pockets (best druggability 0.76). MolNFT v1 #152386 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6IFX
- Type
- protein
- Length
- 480 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal RNA small subunit methyltransferase a
- EC
- 2.1.1.182
- UniProt
- P37468
- Pockets
- 8 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal RNA small subunit methyltransferase a (EC 2.1.1.182) | protein | 234 | 31% helix, 17% strand | P37468 |
| B | Ribosomal RNA small subunit methyltransferase a (EC 2.1.1.182) | protein | 246 | 31% helix, 13% strand | P37468 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 400 | 0.76 | 0.86 | 68 | empty |
| 2 | 249 | 0.70 | 0.85 | 44 | empty |
| 3 | 152 | 0.65 | 0.86 | 28 | empty |
| 4 | 231 | 0.55 | 0.77 | 27 | empty |
| 5 | 73 | 0.50 | 0.84 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 678 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6IFX · Crystal structure of chimeric KsgA with loop 12 from Erm · the same entry in another collection · chain A against A, TM-score 1.00
- P37468 · AlphaFold monomer V2.0 prediction for ribosomal RNA small subunit methyltransferase a… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37468
- Elsewhere: RCSB PDB 6IFX · PDBe 6IFX · UniProt P37468
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