MolNFT v1 · #152385 · protein
Crystal structure of chimeric construct of ksga with loop 1 from erm
6IFW · Ribosomal RNA small subunit methyltransferase a: “Crystal structure of chimeric construct of ksga with loop 1 from erm”. X-ray diffraction, 2 pockets (best druggability 0.81). MolNFT v1 #152385 on GenesisL1: 3D structure, binding…
- PDB
- 6IFW
- Type
- protein
- Length
- 486 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal RNA small subunit methyltransferase a
- EC
- 2.1.1.182
- UniProt
- P37468
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal RNA small subunit methyltransferase a (EC 2.1.1.182) | protein | 264 | 41% helix, 18% strand | P37468 |
| B | Ribosomal RNA small subunit methyltransferase a (EC 2.1.1.182) | protein | 222 | 36% helix, 22% strand | P37468 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 642 | 0.81 | 0.85 | 98 | empty |
| 2 | 59 | 0.31 | 0.75 | 9 | empty |
Interfaces
1 interface between chains.
- A–B · 980 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6IFW · crystal structure of chimeric construct of KsgA with loop 1 from erm · the same entry in another collection · chain A against A, TM-score 1.00
- P37468 · AlphaFold monomer V2.0 prediction for ribosomal RNA small subunit methyltransferase a… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37468
- Elsewhere: RCSB PDB 6IFW · PDBe 6IFW · UniProt P37468
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