MolNFT v1 · #152355 · protein
Complex structure of RAB35 and its effector RUSC2
6IF2 · RAS-related protein rab-35: “Complex structure of RAB35 and its effector RUSC2”. X-ray diffraction, 2 ligands (GTP, MG), 3 pockets (best druggability 0.62). MolNFT v1 #152355 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6IF2
- Type
- protein
- Length
- 373 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related protein rab-35; Iporin
- UniProt
- Q15286, Q8N2Y8
- Ligands
- GTP, MG
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | RAS-related protein rab-35 | protein | 178 | 38% helix, 28% strand | Q15286 |
| A | Iporin | protein | 195 | 64% helix, 6% strand | Q8N2Y8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 261 | 0.62 | 0.81 | 48 | empty |
| 2 | 109 | 0.53 | 0.83 | 29 | MG, GTP |
| 3 | 256 | 0.52 | 0.75 | 41 | empty |
Interfaces
1 interface between chains.
- B–A · 919 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6IF2 · Complex structure of Rab35 and its effector RUSC2 · the same entry in another collection · chain B against B, TM-score 1.00
- Q8N2Y8 · AlphaFold monomer V2.0 prediction for iporin (Q8N2Y8) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q15286 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-35 (Q15286) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15286
- Every structure of UniProt Q8N2Y8
- Elsewhere: RCSB PDB 6IF2 · PDBe 6IF2 · UniProt Q15286 · UniProt Q8N2Y8
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