MolNFT v1 · #152271 · protein

Crystal structure of human MICAL3

6ICI · [F-actin]-monooxygenase MICAL3: “Crystal structure of human MICAL3”. X-ray diffraction, 1 ligand (FAD), 7 pockets (best druggability 0.75). MolNFT v1 #152271 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6ICI
Type: protein
Length: 585 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: [F-actin]-monooxygenase MICAL3
EC: 1.14.13.225
UniProt: Q7RTP6
Ligands: FAD
Pockets: 7 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225)	protein	585	44% helix, 16% strand	Q7RTP6

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	717	0.75	0.80	71	FAD
2	158	0.62	0.85	23	empty
3	330	0.58	0.76	33	empty
4	112	0.50	0.81	19	empty
5	67	0.33	0.75	14	empty

Compared structures

6ICI · Crystal structure of human MICAL3 · the same entry in another collection · chain A against A, TM-score 1.00
Q7RTP6 · AlphaFold monomer V2.0 prediction for [F-actin]-monooxygenase MICAL3 (Q7RTP6) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7RTP6
Elsewhere: RCSB PDB 6ICI · PDBe 6ICI · UniProt Q7RTP6

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