Crystal structure of human alpha-galactosidase a in complex with alpha-galactose configured cyclophellitol aziridine ME737

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• H9T · (1~{S},2~{S},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol · ligand · 2 copies · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 10 copies · chains A, B
• BMA · beta-D-mannopyranose · sugar · 3 copies
• MAN · alpha-D-mannopyranose · sugar · 2 copies
• SO4 · Sulfate ion · ion · 5 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 7 copies · chains A, B
• ACT · Acetate ion · additive · 6 copies · chains A, B
• PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6IBT · Crystal structure of human alpha-galactosidase A in complex with alpha-galactose… · the same entry in another collection · chain A against A, TM-score 1.00
• P06280 · AlphaFold monomer V2.0 prediction for alpha-galactosidase a (P06280) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P06280
• Elsewhere: RCSB PDB 6IBT · PDBe 6IBT · UniProt P06280