MolNFT v1 · #152186 · protein
Urate oxidase under 65 bar of argon
6I9Z · Uricase: “Urate oxidase under 65 bar of argon”. X-ray diffraction, 4 ligands (ACE, AZA, NA), 2 pockets (best druggability 0.53). MolNFT v1 #152186 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6I9Z
- Type
- protein
- Length
- 295 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uricase
- EC
- 1.7.3.3
- UniProt
- Q00511
- Ligands
- ACE, AZA, NA, AR
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uricase (EC 1.7.3.3) | protein | 295 | 28% helix, 39% strand | Q00511 |
Ligands and binding sites
- ACE · Acetyl group · ligand · chains A
- AZA · 8-azaxanthine · ligand · chains A
- NA · Sodium ion · metal · chains A
- AR · Argon · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.53 | 0.78 | 21 | empty |
| 2 | 172 | 0.46 | 0.75 | 21 | AZA |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 6I9Z · urate oxidase under 65 bar of argon · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00511
- Elsewhere: RCSB PDB 6I9Z · PDBe 6I9Z · UniProt Q00511
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