MolNFT v1 · #152030 · protein
X-ray structure of apo human soluble epoxide hydrolase C-terminal domain (hseh ctd)
6I5E · Bifunctional epoxide hydrolase 2: “X-ray structure of apo human soluble epoxide hydrolase C-terminal domain (hseh ctd)”. X-ray diffraction, 3 pockets (best druggability 0.84). MolNFT v1 #152030 on GenesisL1: 3D structure, binding…
- PDB
- 6I5E
- Type
- protein
- Length
- 632 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bifunctional epoxide hydrolase 2
- EC
- 3.3.2.10, 3.1.3.76
- UniProt
- P34913
- Pockets
- 3 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bifunctional epoxide hydrolase 2 (EC 3.3.2.10, 3.1.3.76) | protein | 316 | 40% helix, 16% strand | P34913 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 624 | 0.84 | 0.88 | 51 | empty |
| 2 | 667 | 0.84 | 0.87 | 59 | empty |
| 3 | 50 | 0.29 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 759 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6I5E · X-ray structure of apo human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34913
- Elsewhere: RCSB PDB 6I5E · PDBe 6I5E · UniProt P34913
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