MolNFT v1 · #151941 · protein
Crystal structure of vaccinia virus protein A55 btb-back domain in complex with human cullin-3 N-terminus
6I2M · Kelch repeat and btb domain-containing protein A55: “Crystal structure of vaccinia virus protein A55 btb-back domain in complex with human cullin-3 N-terminus”. X-ray diffraction, 2 pockets (best druggability 0.44). MolNFT v1…
- PDB
- 6I2M
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kelch repeat and btb domain-containing protein A55; Cullin-3
- UniProt
- P24768, Q13618
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kelch repeat and btb domain-containing protein A55 | protein | 196 | 59% helix, 8% strand | P24768 |
| B | Cullin-3 | protein | 343 | 82% helix, 0% strand | Q13618 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.44 | 0.78 | 15 | empty |
| 2 | 52 | 0.36 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1128 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 6I2M · Crystal structure of vaccinia virus protein A55 BTB-Back domain in complex with human… · the same entry in another collection · chain A against A, TM-score 1.00
- Q13618 · AlphaFold monomer V2.0 prediction for cullin-3 (Q13618) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24768
- Every structure of UniProt Q13618
- Elsewhere: RCSB PDB 6I2M · PDBe 6I2M · UniProt P24768 · UniProt Q13618
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