MolNFT v1 · #15193 · protein

Crystal structure of ctbp dehydrogenase core holo form

1MX3 · C-terminal binding protein 1: “Crystal structure of ctbp dehydrogenase core holo form”. X-ray diffraction, 1 ligand (NAD), 2 pockets (best druggability 0.72). MolNFT v1 #15193 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1MX3
Type: protein
Length: 326 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-terminal binding protein 1
UniProt: Q13363
Ligands: NAD
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	C-terminal binding protein 1	protein	326	35% helix, 17% strand	Q13363

Ligands and binding sites

NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
ACY · Acetic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	497	0.72	0.81	55	NAD, ACY
2	118	0.40	0.75	22	empty

Compared structures

1MX3 · Crystal structure of CtBP dehydrogenase core holo form · the same entry in another collection · chain A against A, TM-score 1.00
Q13363 · AlphaFold monomer V2.0 prediction for C-terminal-binding protein 1 (Q13363) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13363
Elsewhere: RCSB PDB 1MX3 · PDBe 1MX3 · UniProt Q13363

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