MolNFT v1 · #151756 · protein
Crystal structure of human R180T variant of ornithine aminotransferase at 1.8 ångström
6HX7 · Ornithine aminotransferase, mitochondrial: “Crystal structure of human R180T variant of ornithine aminotransferase at 1.8 ångström”. X-ray diffraction, 1 ligand (PLP), 15 pockets (best druggability 0.64). MolNFT v1 #151756 on…
- PDB
- 6HX7
- Type
- protein
- Length
- 1,187 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ornithine aminotransferase, mitochondrial
- EC
- 2.6.1.13
- UniProt
- P04181
- Ligands
- PLP
- Pockets
- 15 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) | protein | 394 | 39% helix, 17% strand | P04181 |
| B | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) | protein | 399 | 39% helix, 18% strand | P04181 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 545 | 0.64 | 0.76 | 68 | PLP |
| 2 | 481 | 0.63 | 0.76 | 62 | PLP |
| 3 | 323 | 0.58 | 0.77 | 32 | empty |
| 4 | 285 | 0.57 | 0.77 | 32 | empty |
| 5 | 296 | 0.54 | 0.75 | 47 | PLP |
Interfaces
2 interfaces between chains.
- B–C · 267 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 263 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6HX7 · Crystal structure of human R180T variant of ORNITHINE AMINOTRANSFERASE at 1.8 Angstrom · the same entry in another collection · chain A against A, TM-score 1.00
- P04181 · AlphaFold monomer V2.0 prediction for ornithine aminotransferase, mitochondrial (P04181) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04181
- Elsewhere: RCSB PDB 6HX7 · PDBe 6HX7 · UniProt P04181
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