Research workbench
Crystal structure of human R180T variant of ornithine aminotransferase at 1.8 ångström
Analyse Crystal structure of human R180T variant of ornithine aminotransferase at 1.8… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HX7
- Type
- protein
- Length
- 1,187 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ornithine aminotransferase, mitochondrial
- EC
- 2.6.1.13
- UniProt
- P04181
- Ligands
- PLP
- Pockets
- 15 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) | protein | 394 | 39% helix, 17% strand | P04181 |
| B | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) | protein | 399 | 39% helix, 18% strand | P04181 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 545 | 0.64 | 0.76 | 68 | PLP |
| 2 | 481 | 0.63 | 0.76 | 62 | PLP |
| 3 | 323 | 0.58 | 0.77 | 32 | empty |
| 4 | 285 | 0.57 | 0.77 | 32 | empty |
| 5 | 296 | 0.54 | 0.75 | 47 | PLP |
Interfaces
2 interfaces between chains.
- B–C · 267 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 263 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6HX7 · Crystal structure of human R180T variant of ORNITHINE AMINOTRANSFERASE at 1.8 Angstrom · the same entry in another collection · chain A against A, TM-score 1.00
- P04181 · AlphaFold monomer V2.0 prediction for ornithine aminotransferase, mitochondrial (P04181) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04181
- Elsewhere: RCSB PDB 6HX7 · PDBe 6HX7 · UniProt P04181
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.