MolNFT v1 · #151464 · protein

Structure of ATG14 lir motif bound to GABARAPL1

6HOL · Gamma-aminobutyric acid receptor-associated protein-like 1: “Structure of ATG14 lir motif bound to GABARAPL1”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.56). MolNFT v1 #151464 on GenesisL1: 3D structure…

PDB: 6HOL
Type: protein
Length: 252 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-aminobutyric acid receptor-associated protein-like 1; Beclin 1-associated…
UniProt: Q9H0R8, Q6ZNE5
Ligands: SO4
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Gamma-aminobutyric acid receptor-associated protein-like 1	protein	116	34% helix, 22% strand	Q9H0R8
C, D	Beclin 1-associated autophagy-related key regulator	protein	10	0% helix, 30% strand	Q6ZNE5

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B
GOL · Glycerol · additive · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	337	0.56	0.75	36	SO4

Interfaces

3 interfaces between chains.

B–D · 640 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 604 Å² buried · 6 hydrogen bonds · protein-protein
A–B · 145 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6HOL · Structure of ATG14 LIR motif bound to GABARAPL1 · the same entry in another collection · chain D against D, TM-score 1.00
Q9H0R8 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated… · a predicted model of the same protein · chain A against A, TM-score 0.95
Q6ZNE5 · AlphaFold monomer V2.0 prediction for beclin 1-associated autophagy- related key… · a predicted model of the same protein · chain C against A, TM-score 0.48

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H0R8
Every structure of UniProt Q6ZNE5
Elsewhere: RCSB PDB 6HOL · PDBe 6HOL · UniProt Q9H0R8 · UniProt Q6ZNE5

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