MolNFT v1 · #151414 · protein
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part
6HN4 · Insulin RECEPTOR,INSULIN RECEPTOR,GENERAL control protein…: “Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part”. Electron microscopy, 1 ligand (NAG), 10 pockets (best…
- PDB
- 6HN4
- Type
- protein
- Length
- 700 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin RECEPTOR,INSULIN RECEPTOR,GENERAL control protein GCN4
- EC
- 2.7.10.1
- UniProt
- P06213, P03069
- Ligands
- NAG
- Pockets
- 10 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 7% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Insulin RECEPTOR,INSULIN RECEPTOR,GENERAL control protein GCN4 (EC 2.7.10.1) | protein | 202 | 6% helix, 43% strand | P06213, P03069 |
| F | Insulin RECEPTOR,INSULIN RECEPTOR,GENERAL control protein GCN4 (EC 2.7.10.1) | protein | 498 | 7% helix, 35% strand | P06213, P03069 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 264 | 0.81 | 0.93 | 39 | empty |
| 2 | 218 | 0.61 | 0.82 | 25 | empty |
| 3 | 128 | 0.56 | 0.83 | 24 | empty |
| 4 | 151 | 0.53 | 0.80 | 30 | empty |
| 5 | 127 | 0.40 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- E–F · 1272 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide, 6 glycan (disulfide, N-glycosylation).
Compared structures
- 6HN4 · Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower"… · the same entry in another collection · chain F against F, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain E against A, TM-score 0.95
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain E against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P03069
- Elsewhere: RCSB PDB 6HN4 · PDBe 6HN4 · UniProt P06213 · UniProt P03069
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