MolNFT v1 · #151378 · protein
Crystal structure of RAD4 BRCT1,2 in complex with a MDB1 phosphopeptide
6HM4 · S-M checkpoint control protein RAD4: “Crystal structure of RAD4 BRCT1,2 in complex with a MDB1 phosphopeptide”. X-ray diffraction, 1 pocket (best druggability 0.32). MolNFT v1 #151378 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6HM4
- Type
- protein
- Length
- 191 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-M checkpoint control protein RAD4; DNA damage response protein MDB1
- UniProt
- P32372, O14079
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-M checkpoint control protein RAD4 | protein | 182 | 37% helix, 17% strand | P32372 |
| B | DNA damage response protein MDB1 | protein | 9 | 0% helix, 11% strand | O14079 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.32 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 460 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation, phosphorylation).
Compared structures
- 6HM4 · Crystal structure of Rad4 BRCT1,2 in complex with a Mdb1 phosphopeptide · the same entry in another collection · chain A against A, TM-score 1.00
- P32372 · AlphaFold monomer V2.0 prediction for S-M checkpoint control protein RAD4 (P32372) · a predicted model of the same protein · chain A against A, TM-score 0.99
- O14079 · AlphaFold monomer V2.0 prediction for DNA damage response protein MDB1 (O14079) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32372
- Every structure of UniProt O14079
- Elsewhere: RCSB PDB 6HM4 · PDBe 6HM4 · UniProt P32372 · UniProt O14079
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