MolNFT v1 · #151194 · protein
Crystal structure of the human il-17RC D2-D3-D4 domains in complex with an anti-app tag Fab
6HGA · Interleukin-17 receptor C: “Crystal structure of the human il-17RC D2-D3-D4 domains in complex with an anti-app tag Fab”. X-ray diffraction, 1 ligand (NAG), 7 pockets (best druggability 0.56). MolNFT v1 #151194 on GenesisL1: 3D…
- PDB
- 6HGA
- Type
- protein
- Length
- 704 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-17 receptor C; Anti-app-tag Fab heavy-chain; Anti-app-tag Fab light-chain
- UniProt
- Q8NAC3
- Ligands
- NAG
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Interleukin-17 receptor C | protein | 263 | 11% helix, 41% strand | Q8NAC3 |
| H | Anti-app-tag Fab heavy-chain | protein | 222 | 7% helix, 49% strand | — |
| L | Anti-app-tag Fab light-chain | protein | 219 | 5% helix, 52% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 339 | 0.56 | 0.75 | 40 | empty |
| 2 | 69 | 0.47 | 0.84 | 19 | empty |
| 3 | 124 | 0.40 | 0.75 | 26 | empty |
| 4 | 105 | 0.39 | 0.75 | 16 | empty |
| 5 | 78 | 0.38 | 0.78 | 18 | empty |
Interfaces
3 interfaces between chains.
- H–L · 2059 Ų buried · 30 hydrogen bonds · protein-protein
- B–L · 727 Ų buried · 15 hydrogen bonds · protein-protein
- B–H · 293 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide, 1 glycan, 1 modified (disulfide, N-glycosylation, cyclization).
Compared structures
- 6HGA · Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag… · the same entry in another collection · chain B against B, TM-score 1.00
- Q8NAC3 · AlphaFold monomer V2.0 prediction for interleukin-17 receptor C (Q8NAC3) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NAC3
- Elsewhere: RCSB PDB 6HGA · PDBe 6HGA · UniProt Q8NAC3
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