MolNFT v1 · #151121 · protein
20S core particle of pan-proteasomes
6HE5 · Proteasome subunit alpha: “20S core particle of pan-proteasomes”. Electron microscopy, 20 pockets (best druggability 0.64). MolNFT v1 #151121 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HE5
- Type
- protein
- Length
- 3,162 residues
- Chains
- 20
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha; Proteasome subunit beta; Proteasome-activating nucleotidase
- EC
- 3.4.25.1
- UniProt
- O29760, Q9P996, O28303
- Pockets
- 20 · best druggability 0.64
Structure
electron microscopy · 3 distinct chains · 38% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Proteasome subunit alpha (EC 3.4.25.1) | protein | 242 | 41% helix, 24% strand | O29760 |
| 1, 2, 3, 4, 5, 6, 7 | Proteasome subunit beta (EC 3.4.25.1) | protein | 202 | 35% helix, 28% strand | Q9P996 |
| H, I, K, L, M, J | Proteasome-activating nucleotidase | protein | 9 | 0% helix, 0% strand | O28303 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.64 | 0.80 | 58 | empty |
| 2 | 437 | 0.60 | 0.75 | 67 | empty |
| 3 | 358 | 0.60 | 0.77 | 28 | empty |
| 4 | 338 | 0.58 | 0.77 | 29 | empty |
| 5 | 112 | 0.57 | 0.84 | 25 | empty |
Interfaces
40 interfaces between chains.
- F–G · 1633 Ų buried · 22 hydrogen bonds · protein-protein
- D–E · 1627 Ų buried · 25 hydrogen bonds · protein-protein
- A–G · 1621 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1586 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 1574 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6HE5 · 20S core particle of PAN-proteasomes · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O29760
- Every structure of UniProt Q9P996
- Every structure of UniProt O28303
- Elsewhere: RCSB PDB 6HE5 · PDBe 6HE5 · UniProt O29760 · UniProt Q9P996 · UniProt O28303
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