UniProt Q9P996
Proteasome subunit beta (Q9P996)
Proteasome subunit beta (UniProt Q9P996), EC 3.4.25.1: 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 71 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9P996
- Protein
- Proteasome subunit beta
- EC
- 3.4.25.1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 71 · 6 records with a druggable one
Structures
17 records of Q9P996 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J2Q | 20S proteasome in complex with calpain-Inhibitor I from archaeoglobus fulgidus | x-ray diffraction | H, I, J, K, L, M, N | CIB | 18 (best 0.80) |
| 1J2Q | 20S proteasome in complex with calpain-inhibitor I from archaeoglobus fulgidus | x-ray diffraction | H, I, J, K, L, M, N | — | — |
| 6HE5 | 20S core particle of PAN-proteasomes | electron microscopy | 1, 2, 3, 4, 5, 6, 7 | — | 14 (best 0.64) |
| 6HE5 | 20S core particle of pan-proteasomes | electron microscopy | 1, 2, 3, 4, 5, 6, 7 | — | — |
| 6HE7 | 20S proteasome from Archaeoglobus fulgidus | electron microscopy | 1, 2, 3, 4, 5, 6, 7 | — | 14 (best 0.69) |
| 6HE7 | 20S proteasome from archaeoglobus fulgidus | electron microscopy | 1, 2, 3, 4, 5, 6, 7 | — | — |
| 6HE8 | PAN-proteasome in state 1 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | — |
| 6HE8 | Pan-proteasome in state 1 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | — |
| 6HE9 | PAN-proteasome in state 2 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | 8 (best 0.80) |
| 6HE9 | Pan-proteasome in state 2 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | — |
| 6HEA | PAN-proteasome in state 3 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | — |
| 6HEA | Pan-proteasome in state 3 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | — |
| 6HEC | PAN-proteasome in state 4 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | 7 (best 0.74) |
| 6HEC | Pan-proteasome in state 4 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | — |
| 6HED | PAN-proteasome in state 5 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | 9 (best 0.77) |
| 6HED | Pan-proteasome in state 5 | electron microscopy | 1, h, 2, i, 3, j, 4, k, 5, l, 6, m, 7, n | — | — |
| Q9P996 | AlphaFold monomer V2.0 prediction for proteasome subunit beta (Q9P996) | predicted | A | — | 1 (best 0.42) |
Ligands
- CIB · 2-acetylamino-4-methyl-pentanoic acid [1-(1-formyl-pentylcarbamoyl)-3-methyl-butyl]-amide · in 1 record
Experiment against prediction
- 1J2Q chain H against the predicted model Q9P996: TM-score 0.98, RMSD 0.78 Å
- 1J2Q chain H against the predicted model Q9P996: TM-score 0.98, RMSD 0.78 Å
- 6HE7 chain 2 against the predicted model Q9P996: TM-score 0.94, RMSD 1.49 Å
- 6HE7 chain 7 against the predicted model Q9P996: TM-score 0.94, RMSD 1.49 Å
- 6HE5 chain 7 against the predicted model Q9P996: TM-score 0.94, RMSD 1.50 Å
- 6HED chain 7 against the predicted model Q9P996: TM-score 0.94, RMSD 1.48 Å
- 6HE7 chain 4 against the predicted model Q9P996: TM-score 0.94, RMSD 1.62 Å
- 6HE7 chain 3 against the predicted model Q9P996: TM-score 0.93, RMSD 1.57 Å
- 6HE7 chain 1 against the predicted model Q9P996: TM-score 0.93, RMSD 1.54 Å
- 6HE7 chain 1 against the predicted model Q9P996: TM-score 0.93, RMSD 1.54 Å
Elsewhere
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