MolNFT v1 · #150850 · protein
QTRT1, the catalytic subunit of murine tRNA-guanine transglycosylase
6H62 · Queuine tRNA-ribosyltransferase catalytic subunit 1: “QTRT1, the catalytic subunit of murine tRNA-guanine transglycosylase”. X-ray diffraction, 1 ligand (ZN), 9 pockets (best druggability 0.73). MolNFT v1 #150850 on GenesisL1: 3D…
- PDB
- 6H62
- Type
- protein
- Length
- 736 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Queuine tRNA-ribosyltransferase catalytic subunit 1
- EC
- 2.4.2.29
- UniProt
- Q9JMA2
- Ligands
- ZN
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.29) | protein | 370 | 42% helix, 19% strand | Q9JMA2 |
| B | Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.29) | protein | 366 | 43% helix, 19% strand | Q9JMA2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 688 | 0.73 | 0.79 | 95 | empty |
| 2 | 405 | 0.65 | 0.79 | 57 | empty |
| 3 | 58 | 0.45 | 0.83 | 14 | empty |
| 4 | 83 | 0.43 | 0.79 | 17 | empty |
| 5 | 69 | 0.41 | 0.80 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 815 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6H62 · QTRT1, the catalytic subunit of murine tRNA-Guanine Transglycosylase · the same entry in another collection · chain A against A, TM-score 1.00
- Q9JMA2 · AlphaFold monomer V2.0 prediction for queuine tRNA-ribosyltransferase catalytic subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9JMA2
- Elsewhere: RCSB PDB 6H62 · PDBe 6H62 · UniProt Q9JMA2
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