MolNFT v1 · #150803 · protein
Crystal structure of human KDM4A in complex with compound 18A
6H4O: “Crystal structure of human KDM4A in complex with compound 18A”. X-ray diffraction, 3 ligands (FQH, ZN, CL). MolNFT v1 #150803 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6H4O
- Type
- protein
- Length
- 1,358 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O75164
- Ligands
- FQH, ZN, CL
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 338 | — | O75164 |
| B | — | protein | 339 | — | O75164 |
| C | — | protein | 341 | — | O75164 |
| D | — | protein | 340 | — | O75164 |
Ligands and binding sites
- FQH · 8-[4-[2-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one · ligand · 4 copies · chains A, B, C, D
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
- CL · Chloride ion · ion · 2 copies · chains A
- DMS · Dimethyl sulfoxide · additive · 3 copies · chains C, D
- GOL · Glycerol · additive · 2 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6H4O · Crystal structure of human KDM4A in complex with compound 18a · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75164
- Elsewhere: RCSB PDB 6H4O · PDBe 6H4O · UniProt O75164
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