MolNFT v1 · #150767 · protein

The crystal structure of a human seleno-insulin analog

6H3M: “The crystal structure of a human seleno-insulin analog”. X-ray diffraction, 3 pockets (best druggability 0.43). MolNFT v1 #150767 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6H3M
Type: protein
Length: 401 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin
UniProt: P01308
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 4 distinct chains · 52% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G, I, K, N, R	Insulin	protein	21	57% helix, 5% strand	P01308
B, F, H	Insulin	protein	29	48% helix, 10% strand	P01308
D, L, P	Insulin	protein	30	50% helix, 3% strand	P01308
J, Q	Insulin	protein	28	54% helix, 4% strand	P01308

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.43	0.79	27	empty
2	66	0.34	0.76	15	empty
3	50	0.32	0.77	14	empty

Interfaces

61 interfaces between chains.

C–D · 829 Å² buried · 11 hydrogen bonds · protein-protein
F–K · 817 Å² buried · 11 hydrogen bonds · protein-protein
P–R · 743 Å² buried · 10 hydrogen bonds · protein-protein
H–G · 740 Å² buried · 8 hydrogen bonds · protein-protein
L–I · 722 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

6H3M · The crystal structure of a human seleno-insulin analog · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 6H3M · PDBe 6H3M · UniProt P01308

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.