MolNFT v1 · #150735 · protein
Apo structure of phenylalanine ammonia-lyase from petroselinum crispum
6H2O · Phenylalanine ammonia-lyase 1: “Apo structure of phenylalanine ammonia-lyase from petroselinum crispum”. X-ray diffraction, 19 pockets (best druggability 0.80). MolNFT v1 #150735 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6H2O
- Type
- protein
- Length
- 1,287 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine ammonia-lyase 1
- EC
- 4.3.1.24
- UniProt
- P24481
- Pockets
- 19 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanine ammonia-lyase 1 (EC 4.3.1.24) | protein | 642 | 62% helix, 4% strand | P24481 |
| B | Phenylalanine ammonia-lyase 1 (EC 4.3.1.24) | protein | 645 | 60% helix, 4% strand | P24481 |
Pockets
19 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1096 | 0.80 | 0.81 | 85 | empty |
| 2 | 165 | 0.52 | 0.79 | 32 | empty |
| 3 | 172 | 0.48 | 0.77 | 26 | empty |
| 4 | 154 | 0.48 | 0.77 | 25 | empty |
| 5 | 164 | 0.46 | 0.76 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 3608 Ų buried · 61 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (nonstandard).
Compared structures
- 6H2O · APO structure of Phenylalanine ammonia-lyase from Petroselinum crispum · the same entry in another collection · chain B against B, TM-score 1.00
- P24481 · AlphaFold monomer V2.0 prediction for phenylalanine ammonia-lyase 1 (P24481) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24481
- Elsewhere: RCSB PDB 6H2O · PDBe 6H2O · UniProt P24481
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