MolNFT v1 · #150557 · protein + RNA
Crystal structure of IMP3 RRM12 in complex with RNA (acac)
6GX6 · Insulin-like growth factor 2 mRNA-binding protein 3: “Crystal structure of IMP3 RRM12 in complex with RNA (acac)”. X-ray diffraction, 1 ligand (PO4), 2 pockets (best druggability 0.40). MolNFT v1 #150557 on GenesisL1: 3D structure…
- PDB
- 6GX6
- Type
- protein + RNA
- Length
- 163 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 2 mRNA-binding protein 3; RNA (5'-R(*AP*CP*AP*C)-3')
- UniProt
- O00425
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 2 mRNA-binding protein 3 | protein | 159 | 27% helix, 30% strand | O00425 |
| B | RNA (5'-R(*AP*CP*AP*C)-3') | rna | 4 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.40 | 0.76 | 15 | EDO, PO4 |
| 2 | 61 | 0.34 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 416 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 6GX6 · Crystal structure of IMP3 RRM12 in complex with RNA (ACAC) · the same entry in another collection · chain A against A, TM-score 1.00
- O00425 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 2 mRNA-binding protein 3… · a predicted model of the same protein · chain A against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00425
- Elsewhere: RCSB PDB 6GX6 · PDBe 6GX6 · UniProt O00425
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