MolNFT v1 · #150553 · protein
Blood group synthase aaglyb in complex with udp-galnac and cryoprotected with glycerol
6GX2 · Abo blood group (transferase a, alpha 1-3-N…: “Blood group synthase aaglyb in complex with udp-galnac and cryoprotected with glycerol”. X-ray diffraction, 3 ligands (UDP, MN, SO4), 2 pockets (best druggability 0.74). MolNFT v1…
- PDB
- 6GX2
- Type
- protein
- Length
- 297 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Abo blood group (transferase a, alpha 1-3-N- acetylgalactosaminyltransferase transferase…
- UniProt
- F0X360
- Ligands
- UDP, MN, SO4
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Abo blood group (transferase a, alpha 1-3-N- acetylgalactosaminyltransferase transferase B, alpha 1-3- galactosyltransferase) | protein | 297 | 34% helix, 19% strand | F0X360 |
Ligands and binding sites
- UDP · Uridine-5'-diphosphate · ligand · chains A
- MN · Manganese (II) ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- EDO · 1,2-ethanediol · additive · 3 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 453 | 0.74 | 0.83 | 44 | UDP, GOL |
| 2 | 84 | 0.33 | 0.74 | 18 | empty |
Compared structures
- 6GX2 · Blood group synthase AAGlyB in complex with UDP-GalNAc and cryoprotected with glycerol · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F0X360
- Elsewhere: RCSB PDB 6GX2 · PDBe 6GX2 · UniProt F0X360
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