MolNFT v1 · #150443 · protein

Human STK10 bound to birb-796

6GTT · SERINE/THREONINE-protein kinase 10: “Human STK10 bound to birb-796”. X-ray diffraction, 1 ligand (B96), 2 pockets (best druggability 0.72). MolNFT v1 #150443 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6GTT
Type: protein
Length: 282 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase 10
EC: 2.7.11.1
UniProt: O94804
Ligands: B96
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase 10 (EC 2.7.11.1)	protein	282	39% helix, 15% strand	O94804

Ligands and binding sites

B96 · 1-(5-tert-butyl-2-P-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	484	0.72	0.81	53	B96
2	96	0.39	0.76	21	empty

Compared structures

6GTT · Human STK10 bound to BIRB-796 · the same entry in another collection · chain A against A, TM-score 1.00
O94804 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 10 (O94804) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O94804
Elsewhere: RCSB PDB 6GTT · PDBe 6GTT · UniProt O94804

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