MolNFT v1 · #150419 · protein
METTL16 mtase domain (crystal form 2)
6GT5 · U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase: “METTL16 mtase domain (crystal form 2)”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #150419 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6GT5
- Type
- protein
- Length
- 506 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
- EC
- 2.1.1.346, 2.1.1.62
- UniProt
- Q86W50
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC 2.1.1.346, 2.1.1.62) | protein | 254 | 41% helix, 22% strand | Q86W50 |
| B | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase (EC 2.1.1.346, 2.1.1.62) | protein | 252 | 41% helix, 21% strand | Q86W50 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 454 | 0.68 | 0.79 | 43 | empty |
| 2 | 310 | 0.62 | 0.79 | 52 | empty |
| 3 | 186 | 0.61 | 0.83 | 30 | empty |
| 4 | 244 | 0.53 | 0.77 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 651 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86W50
- Elsewhere: RCSB PDB 6GT5 · PDBe 6GT5 · UniProt Q86W50
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