MolNFT v1 · #150360 · protein
Human aurkc incenp complex bound to vx-680
6GR9: “Human aurkc incenp complex bound to vx-680”. X-ray diffraction, 2 ligands (VX6, SO4). MolNFT v1 #150360 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GR9
- Type
- protein
- Length
- 317 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9UQB9, Q9NQS7
- Ligands
- VX6, SO4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 269 | — | Q9UQB9 |
| B | — | protein | 48 | — | Q9NQS7 |
Ligands and binding sites
- VX6 · Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide · ligand · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6GR9 · Human AURKC INCENP complex bound to VX-680 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UQB9 · AlphaFold monomer V2.0 prediction for aurora kinase C (Q9UQB9) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9NQS7 · AlphaFold monomer V2.0 prediction for inner centromere protein (Q9NQS7) · a predicted model of the same protein · chain B against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UQB9
- Every structure of UniProt Q9NQS7
- Elsewhere: RCSB PDB 6GR9 · PDBe 6GR9 · UniProt Q9UQB9 · UniProt Q9NQS7
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