MolNFT v1 · #15033 · protein
Crystal structure of an inactive AKT2 kinase domain
1MRY · Rac-beta SERINE/THREONINE kinase: “Crystal structure of an inactive AKT2 kinase domain”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #15033 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MRY
- Type
- protein
- Length
- 270 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rac-beta SERINE/THREONINE kinase
- EC
- 2.7.11.1
- UniProt
- P31751
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rac-beta SERINE/THREONINE kinase (EC 2.7.11.1) | protein | 270 | 34% helix, 16% strand | P31751 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.59 | 0.81 | 38 | empty |
| 2 | 191 | 0.59 | 0.81 | 22 | empty |
| 3 | 68 | 0.34 | 0.76 | 16 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1MRY · crystal structure of an inactive akt2 kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
- P31751 · AlphaFold monomer V2.0 prediction for rac-beta SERINE/THREONINE- protein kinase (P31751) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31751
- Elsewhere: RCSB PDB 1MRY · PDBe 1MRY · UniProt P31751
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