MolNFT v1 · #15030 · protein
Crystal structure of an inactive AKT2 kinase domain
1MRV · Rac-beta SERINE/THREONINE kinase: “Crystal structure of an inactive AKT2 kinase domain”. X-ray diffraction, 4 pockets (best druggability 0.58). MolNFT v1 #15030 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MRV
- Type
- protein
- Length
- 261 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rac-beta SERINE/THREONINE kinase
- EC
- 2.7.1.-
- UniProt
- P31751
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rac-beta SERINE/THREONINE kinase (EC 2.7.1.-) | protein | 261 | 34% helix, 18% strand | P31751 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.58 | 0.84 | 25 | empty |
| 2 | 149 | 0.48 | 0.77 | 27 | empty |
| 3 | 100 | 0.40 | 0.76 | 17 | empty |
| 4 | 55 | 0.31 | 0.76 | 16 | empty |
Compared structures
- 1MRV · crystal structure of an inactive Akt2 kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
- P31751 · AlphaFold monomer V2.0 prediction for rac-beta SERINE/THREONINE- protein kinase (P31751) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31751
- Elsewhere: RCSB PDB 1MRV · PDBe 1MRV · UniProt P31751
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