MolNFT v1 · #150195 · protein
Structure of H. sapiens SPT6 tandem SH2 domain
6GME · SPT6 tandem SH2 DOMAIN,TRANSCRIPTION elongation factor SPT6: “Structure of H. sapiens SPT6 tandem SH2 domain”. X-ray diffraction, 2 pockets (best druggability 0.84). MolNFT v1 #150195 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GME
- Type
- protein
- Length
- 379 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SPT6 tandem SH2 DOMAIN,TRANSCRIPTION elongation factor SPT6
- UniProt
- Q7KZ85
- Pockets
- 2 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SPT6 tandem SH2 DOMAIN,TRANSCRIPTION elongation factor SPT6 | protein | 190 | 33% helix, 31% strand | Q7KZ85 |
| B | SPT6 tandem SH2 DOMAIN,TRANSCRIPTION elongation factor SPT6 | protein | 189 | 33% helix, 31% strand | Q7KZ85 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1110 | 0.84 | 0.85 | 96 | empty |
| 2 | 238 | 0.58 | 0.79 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1267 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7KZ85
- Elsewhere: RCSB PDB 6GME · PDBe 6GME · UniProt Q7KZ85
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