UniProt Q7KZ85
Transcription elongation factor SPT6 (Q7KZ85)
Transcription elongation factor SPT6 (UniProt Q7KZ85): 22 experimental structures and 1 predicted model on GenesisL1, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7KZ85
- Protein
- Transcription elongation factor SPT6
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 29 · 9 records with a druggable one
Structures
23 records of Q7KZ85 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6GME | Structure of H. sapiens SPT6 tandem SH2 domain | x-ray diffraction | A, B | — | — |
| 6GME | Structure of H. sapiens SPT6 tandem SH2 domain | x-ray diffraction | A, B | — | — |
| 6GMH | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | electron microscopy | M | — | — |
| 6GMH | Structure of activated transcription complex pol II-dsif-paf-SPT6 | electron microscopy | M | — | — |
| 6TED | Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric… | electron microscopy | M | — | — |
| 6TED | Structure of complete, activated transcription complex pol II-dsif- paf-SPT6 uncovers allosteric… | electron microscopy | M | — | — |
| 7OOP | Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | electron microscopy | M | — | 1 (best 0.81) |
| 7OOP | Pol II-csb-csa-DDB1-uvssa-paf-SPT6 (structure 3) | electron microscopy | M | — | — |
| 7OPC | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4) | electron microscopy | M | — | 2 (best 0.79) |
| 7OPC | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) | electron microscopy | M | — | — |
| 7OPD | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 5) | electron microscopy | M | — | 3 (best 0.79) |
| 7OPD | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) | electron microscopy | M | — | — |
| 7UNC | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | electron microscopy | M | — | 1 (best 0.72) |
| 7UND | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | electron microscopy | M | — | — |
| 8OEU | Structure of the mammalian Pol II-SPT6 complex (composite structure, Structure 4) | electron microscopy | S | — | 1 (best 0.80) |
| 8OEV | Structure of the mammalian Pol II-SPT6-Elongin complex, lacking ELOA latch (composite structure… | electron microscopy | S | — | 2 (best 0.83) |
| 8OF0 | Structure of the mammalian Pol II-SPT6-Elongin complex, Structure 1 | electron microscopy | S | — | 2 (best 0.85) |
| 9EGX | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | electron microscopy | M | — | — |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | M | — | — |
| 9EGZ | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 | electron microscopy | M | — | — |
| 9EH0 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 30 bp upstream | electron microscopy | M | — | — |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | M | — | 2 (best 0.83) |
| Q7KZ85 | AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (Q7KZ85) | predicted | A | — | 15 (best 0.81) |
Experiment against prediction
- 8OEV chain S against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.27 Å
- 8OEU chain S against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.27 Å
- 7OPC chain M against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.46 Å
- 7OPC chain M against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.46 Å
- 7OPD chain M against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.46 Å
- 7OPD chain M against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.46 Å
- 7OOP chain M against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.58 Å
- 7OOP chain M against the predicted model Q7KZ85: TM-score 0.98, RMSD 1.58 Å
- 8OF0 chain S against the predicted model Q7KZ85: TM-score 0.97, RMSD 1.68 Å
- 9EH2 chain M against the predicted model Q7KZ85: TM-score 0.88, RMSD 3.30 Å
Elsewhere
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