MolNFT v1 · #150073 · protein
Structure of GLUA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and rubidium bromide at 1.75 a resolution
6GIV · Glutamate receptor 2: “Structure of GLUA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and rubidium bromide at 1.75…”. X-ray diffraction, 3 ligands (GLU, SO4, BR), 2 pockets (best druggability 0.42). MolNFT v1…
- PDB
- 6GIV
- Type
- protein
- Length
- 262 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P19491
- Ligands
- GLU, SO4, BR
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 2 | protein | 262 | 38% helix, 21% strand | P19491 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · chains A
- SO4 · Sulfate ion · ion · chains A
- BR · Bromide ion · ion · chains A
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.42 | 0.77 | 21 | SO4 |
| 2 | 80 | 0.38 | 0.77 | 21 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6GIV · Structure of GluA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and… · the same entry in another collection · chain A against A, TM-score 1.00
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 6GIV · PDBe 6GIV · UniProt P19491
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.