MolNFT v1 · #149843 · protein + RNA
Molecular basis for au-rich element recognition and dimerization by the hur C-terminal rrm
6GC5 · Elav-like protein 1: “Molecular basis for au-rich element recognition and dimerization by the hur C-terminal rrm”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #149843 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6GC5
- Type
- protein + RNA
- Length
- 326 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elav-like protein 1; Au-rich RNA
- UniProt
- Q15717
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 6 distinct chains · 28% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Elav-like protein 1 | protein | 79 | 28% helix, 39% strand | Q15717 |
| B | Elav-like protein 1 | protein | 76 | 29% helix, 41% strand | Q15717 |
| D | Elav-like protein 1 | protein | 77 | 29% helix, 34% strand | Q15717 |
| E | Au-rich RNA | rna | 5 | — | — |
| F, H | Au-rich RNA | rna | 3 | — | — |
| G | Au-rich RNA | rna | 4 | — | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.33 | 0.74 | 28 | empty |
Interfaces
7 interfaces between chains.
- A–E · 649 Ų buried · 19 hydrogen bonds · protein-nucleic
- C–G · 542 Ų buried · 12 hydrogen bonds · protein-nucleic
- B–F · 429 Ų buried · 8 hydrogen bonds · protein-nucleic
- D–H · 426 Ų buried · 9 hydrogen bonds · protein-nucleic
- B–C · 365 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6GC5 · Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM · the same entry in another collection · chain H against H, TM-score 1.00
- Q15717 · AlphaFold monomer V2.0 prediction for elav-like protein 1 (Q15717) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15717
- Elsewhere: RCSB PDB 6GC5 · PDBe 6GC5 · UniProt Q15717
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