MolNFT v1 · #149824 · protein + RNA
Solution structure of fus-rrm bound to stem-loop RNA
6GBM · RNA-binding protein fus: “Solution structure of fus-rrm bound to stem-loop RNA”. Solution nmr, 2 pockets (best druggability 0.54). MolNFT v1 #149824 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GBM
- Type
- protein + RNA
- Length
- 125 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-binding protein fus; RNA (5'- R(*GP*GP*CP*AP*GP*AP*UP*UP*AP*CP*AP*AP*UP*UP*CP*UP*AP*UP…
- UniProt
- P35637
- Pockets
- 2 · best druggability 0.54
Structure
solution nmr · 2 distinct chains · 23% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | RNA-binding protein fus | protein | 102 | 23% helix, 29% strand | P35637 |
| A | RNA (5'- R(*GP*GP*CP*AP*GP*AP*UP*UP*AP*CP*AP*AP*UP*UP*CP*UP*AP*UP*UP*UP*GP*CP* C)-3') | rna | 23 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.54 | 0.81 | 21 | empty |
| 2 | 209 | 0.49 | 0.76 | 27 | empty |
Interfaces
1 interface between chains.
- B–A · 1151 Ų buried · 32 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35637
- Elsewhere: RCSB PDB 6GBM · PDBe 6GBM · UniProt P35637
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