MolNFT v1 · #149768 · protein
Crystal structure of human histidine triad nucleotide-binding protein 1 (HHINT1) crystallized at P212121 space group, with visible extended fragment of N-terminus
6G9Z: “Crystal structure of human histidine triad nucleotide-binding protein 1 (HHINT1) crystallized at P212121…”. X-ray diffraction, 1 ligand (LMR), 2 pockets (best druggability 0.49). MolNFT v1 #149768 on GenesisL1: 3D structure, binding…
- PDB
- 6G9Z
- Type
- protein
- Length
- 239 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidine triad nucleotide-binding protein 1
- EC
- 3.-.-.-
- UniProt
- P49773
- Ligands
- LMR
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) | protein | 121 | 24% helix, 23% strand | P49773 |
| B | Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) | protein | 118 | 28% helix, 24% strand | P49773 |
Ligands and binding sites
- LMR · (2S)-2-hydroxybutanedioic acid · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.49 | 0.77 | 27 | LMR |
| 2 | 77 | 0.34 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 2015 Ų buried · 45 hydrogen bonds · protein-protein
Compared structures
- 6G9Z · Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49773
- Elsewhere: RCSB PDB 6G9Z · PDBe 6G9Z · UniProt P49773
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.