MolNFT v1 · #149664 · protein

Structure of murine PRPF39

6G70 · Pre-mRNA-processing factor 39: “Structure of murine PRPF39”. X-ray diffraction, 19 pockets (best druggability 0.75). MolNFT v1 #149664 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6G70
Type: protein
Length: 1,019 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-processing factor 39
UniProt: E9QJV4
Pockets: 19 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-processing factor 39	protein	509	78% helix, 0% strand	E9QJV4
B	Pre-mRNA-processing factor 39	protein	510	78% helix, 0% strand	E9QJV4

Pockets

19 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	744	0.75	0.80	53	empty
2	330	0.59	0.76	30	empty
3	86	0.53	0.84	16	empty
4	91	0.53	0.84	16	empty
5	148	0.51	0.78	19	empty

Interfaces

1 interface between chains.

A–B · 1674 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

6G70 · Structure of murine Prpf39 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E9QJV4
Elsewhere: RCSB PDB 6G70 · PDBe 6G70 · UniProt E9QJV4

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