MolNFT v1 · #14960 · protein

Crystal structure of the free human NKG2D immunoreceptor

1MPU · NKG2-D type II integral membrane protein: “Crystal structure of the free human NKG2D immunoreceptor”. X-ray diffraction, 1 ligand (PO4), 1 pocket (best druggability 0.35). MolNFT v1 #14960 on GenesisL1: 3D structure, binding sites…

PDB: 1MPU
Type: protein
Length: 128 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NKG2-D type II integral membrane protein
UniProt: P26718
Ligands: PO4
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NKG2-D type II integral membrane protein	protein	128	12% helix, 35% strand	P26718

Ligands and binding sites

PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.35	0.77	15	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1MPU · Crystal Structure of the free human NKG2D immunoreceptor · the same entry in another collection · chain A against A, TM-score 1.00
P26718 · AlphaFold monomer V2.0 prediction for NKG2-D type II integral membrane protein (P26718) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26718
Elsewhere: RCSB PDB 1MPU · PDBe 1MPU · UniProt P26718

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